Sugar acids and derivatives
Medchemexpress LLC Naproxen glucuronide 1mg
Naproxen glucuronide ((S)-Naproxen- -D-glucuronide) is a non-selective COX inhibitor Naproxen glucuronide a metabolite of naproxen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same as ibuprofen) that relieves pain fever swelling and stiffness[1]
Medchemexpress LLC Fenclofenac 25mg | 34645-84-6 | 25 MG
Fenclofenac is a nonsteroidal anti-inflammatory drug (NSAID) supplied as a research-grade analytical standard for inflammation studies. It exhibits antipyretic and analgesic activity and is provided as a white to off-white solid.
- High purity (99.1%).
- Molecular weight 297.13 g/mol.
- Chemical formula C14H10Cl2O3.
- White to off-white solid for analytical use.
- Packaged as 25 MG vials, multiple sizes available.
- Store sealed, away from moisture; follow recommended cold storage for solutions.
Medchemexpress LLC IFN-beta Rhesus Mac 10ug
IFN-beta Protein Rhesus Macaque (HEK293 Fc Solution) is the recombinant rhesus macaque-derived IFN-beta protein expressed by HEK293 with C-mFc tag
BIOHIPPO T-bet-TAR-Puro LV
T-bet-TAR-Puro is a transcription factor reporter lentiviral vector designed to monitor the target signaling pathway in living cells The construct carries a fluorescent reporter gene under the control of pathway responsive elements and includes a puromycin selection marker to generate stable cell pools The lentivirus is provided as a ready to use VSV G pseudotyped preparation for efficient gene delivery and stable genomic integration Each vial provides a nominal titer of 5x10E6 transducing units TU Typical applications include pathway activation studies assay development compound screening and mechanism of action research The system is suitable for human and mouse cells and can be read using standard fluorescence microscopy flow cytometry or luciferase assays depending on the reporter gene This product is intended for research use only and is not for diagnostic or therapeutic procedures
Sigma Aldrich Fine Chemicals Biosciences 3dGROTM Colon Intestinal O
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Amsbio LLC Heparan Sulfate
Major disaccharide units: GlcA-GlcNAc and IdoA/GlcA-GlcNS (variable O-sulphation). Degree of N-sulphation 65 (N-sulphates/100 disaccharides). Ratio N-sulphation:O-sulphation = 0.73. Single band on agarose gel electrophoresis. Contains both low and high sulphated heparan sulphates.
Medchemexpress LLC Bet-in-19 (compound 146) | 1643947-30-1 | 99.7% | 333.39 g/mol | C19H19N5O | 10MM 1ML
BET-IN-19 is a small-molecule inhibitor of BET family bromodomains used in epigenetic and oncology research. It inhibits tetra-acetylated histone H4 binding to BRD4 bromodomain 1 and has demonstrated cellular activity in reported assays (IC50 ≤0.3 μM). Supplied as a powder for laboratory research.
- Small-molecule BET bromodomain inhibitor for epigenetic and oncology research.
- Demonstrated cellular activity with IC50 ≤0.3 μM in reported assays.
- High purity (99.74%) suitable for in vitro studies.
- Molecular formula C19H19N5O, molecular weight 333.39 g/mol.
- Supplied as a powder; storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Soluble in DMSO at 100 mg/mL (≈299.95 mM); ultrasonic assistance may be required for dissolution.
![Medchemexpress LLC 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)-4-pyridinyl]benzamide | 1258292-64-6 | ≥98.0% | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231850.png-250.jpg)
Medchemexpress LLC 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)-4-pyridinyl]benzamide | 1258292-64-6 | ≥98.0% | 50 MG
GDC-046 is a small-molecule TYK2 inhibitor for research use. It is potent, selective, and orally bioavailable, with reported Ki values of 4.8 nM for TYK2 and 0.7 nM, 0.7 nM, and 0.4 nM for JAK1, JAK2, and JAK3, respectively.
- Potent and selective TYK2 inhibitor with low nanomolar Ki values.
- Orally bioavailable small molecule suitable for in vitro and in vivo studies.
- High purity material (≥98%).
- Molecular formula C16H13Cl2N3O2 and molecular weight 350.2 g/mol.
- Intended for research use only; not for human or clinical use.
- Supplied as a 50 MG quantity.
Medchemexpress LLC β-D-glucuronide-pNP-carbonate | 894095-98-8 | MFCD31715405 | 99.6% | 913.83 | C45H43N3O18 | 250 MG
β-D-glucuronide-pNP-carbonate is a cleavable glucuronide-based carbonate linker used as a precursor in antibody-drug conjugate (ADC) synthesis. It features a p-nitrophenyl (pNP) activated carbonate that facilitates conjugation and enzymatic payload release upon glucuronidase cleavage. Supplied as a white to off-white solid with high purity and defined molecular properties, it is intended for research applications.
- Cleavable glucuronide-based ADC linker for payload release
- Activated p-nitrophenyl carbonate handle for efficient conjugation
- High purity (99.6%) suitable for research applications
- Molecular weight 913.83 and formula C45H43N3O18
- Store at -20°C, sealed and protected from moisture
Medchemexpress LLC Complement factor D-IN-1 | 1386455-76-0 | 98.9% | 483.32 g·mol⁻1 | C21H19BrN6O3 | 10 MG
Complement factor D-IN-1 is a potent, selective, small-molecule reversible inhibitor of complement factor D intended for research into complement system biology and complement-mediated inflammation. It has been characterized in biochemical assays and is supplied as solid or solution for laboratory studies.
- Potent inhibitory activity: IC50 = 0.006 μM (FD thioesterolytic assay) and IC50 = 0.05 μM (MAC deposition assay).
- High reported purity (~98.9%); consult lot-specific COA for exact value.
- Supplied as solid or as DMSO solution for flexible experimental workflows.
- Stable storage: powder at -20°C (long term) or 4°C; in solvent, -80°C recommended.
- Molecular weight 483.32 g·mol⁻1 and formula C21H19BrN6O3 for analytical reference.
- For research use only; not for human or clinical applications.
Cayman Chemical EthylD-GlucuronIde-d5 10mg
An internal standard for the quantification of ethyl-β-D-glucuronide by GC- or LC-MS
Medchemexpress LLC 4-Methylumbelliferyl 25mg | 18323-58-5 | 440.61 | C28H40O4 | 25 MG
4-Methylumbelliferyl oleate is a fluorogenic substrate used to measure lipase activity; enzymatic hydrolysis liberates 4-methylumbelliferone, a fluorescent reporter (Ex/Em = 320/450 nm). The material is supplied as a 25 mg vial, is soluble in DMSO, and should be stored protected from light at -20°C.